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    Calcium channel blockers Verapamil Inhibition of CYP 3A4 and Pgp by imatinib verapamil exposure 9, 23, 24, 55, 69 72 Inhibition of CYP 3A4 and Pgp by verapamil imatinib exposure 24, 69, 70, 72 Inhibition of CYP 3A4 by dasatinib verapamil exposure 9, 18 Inhibition of CYP 3A4 and Pgp by verapamil dasatinib exposure 9, 10, 52, 67, 68 Inhibition of CYP 3A4 and Pgp by nilotinib verapamil exposure 9, 18, 19, 25, 73 Inhibition of CYP 3A4 by verapamil nilotinib exposure 9, 18, 19 Diltiazem Inhibition of CYP 3A4 by imatinib diltiazem exposure 9, 18 Inhibition of CYP 3A4 and Pgp by diltiazem imatinib exposure 9, 23, 24, 55, 69 72 Inhibition of CYP 3A4 by dasatinib diltiazem exposure 9, 18 Inhibition of CYP 3A4 and Pgp by diltiazem dasatinib exposure 9, 10, 52, 67, 68 Inhibition of CYP 3A4 by nilotinib diltiazem exposure 9, 18 Inhibition of CYP 3A4 by diltiazem nilotinib exposure 9, 18, 19 Nifedipine Inhibition of CYP 3A4 by imatinib nifedipine exposure 9, 18, 74 Inhibition of CYP 3A4 by dasatinib nifedipine exposure 9, 18, 74 Inhibition of CYP3A4 by nilotinib nifedipine exposure 9, 18, 74 Amlodipine Inhibition of CYP 3A4 by imatinib amlodipine exposure 9, 18, 19 Inhibition of CYP 3A4 by dasatinib amlodipine exposure 9, 18, 19 Inhibition of CYP 3A4 by nilotinib amlodipine exposure 9, 18, 19 NO precursors Molsidomine Isosorbid mononitrate ISMN Inhibition of CYP 3A4 by imatinib ISMN exposure 9, 18, 19 Inhibition of CYP 3A4 by dasatinib ISMN exposure 9, 18, 19 Inhibition of CYP 3A4 by nilotinib ISMN exposure 9, 18, 19 Isosorbid dinitrate ISDN Inhibition of CYP 3A4 by imatinib ISDN exposure 9, 18, 19 Inhibition of CYP 3A4 by dasatinib ISDN exposure 9, 18, 19 Inhibition of CYP 3A4 by nilotinib ISDN exposure 9, 18, 19 Nitroglycerine HMG CoA reductase inhibitors Simvastatin Inhibition of CYP 3A4 by imatinib simvastatin exposure 9, 18, 19, 48 Inhibition of Pgp by simvastatin imatinib exposure 9, 23, 24, 55, 69 72 Inhibition of CYP 3A4 by dasatinib simvastatin exposure 9, 18, 19, 48 Inhibition of Pgp by simvastatin dasatinib exposure 9, 10, 52, 67, 68 Inhibition of CYP 3A4 by nilotinib simvastatin exposure 9, 18, 19 Pravastatin Atorvastatin Inhibition of CYP 3A4 by imatinib atorvastatin exposure 9, 18, 19 Inhibition of Pgp by atorvastatin imatinib exposure 9, 23, 24, 55, 69 72 Inhibition of CYP 3A4 by dasatinib atorvastatin exposure 9, 18, 19 Inhibition of Pgp by atorvastatin dasatinib exposure 9, 10, 67, 68 Inhibition of CYP 3A4 by nilotinib atorvastatin exposure 9, 18, 19 Rosuvastatin Antiarrhythmic drugs Amiodarone Inhibition of CYP 3A4 and Pgp by imatinib amiodarone exposure 9, 23, 24, 69, 70, 72, 75 Inhibition of CYP3A4 and Pgp by amiodarone imatinib exposure 9, 23, 24, 69, 70, 72, 75 Inhibition of hOCT1 by amiodarone imatinib intracellular exposure 9, 18, 64 Inhibition of CYP 3A4 by dasatinib amiodarone exposure 9, 23, 24, 69, 70, 72, 75 Inhibition of CYP 3A4 and Pgp by amiodarone dasatinib exposure 9, 10, 67, 68, 75 QT interval 19 additive effect monitor ECG Inhibition of Pgp and CYP 3A4 by nilotinib amiodarone exposure 9, 18, 19, 25, 73 Inhibition of CYP 3A4 by amiodarone nilotinib exposure 9, 18, 19 QT interval 19 additive effect monitor ECG Quinidine Inhibition of CYP 3A4 by imatinib quinidine exposure 9, 18, 19 Inhibition of Pgp by quinidine imatinib exposure 9, 23, 24, 55, 69 72 Inhibition of hOCT1 by quinidine imatinib intracellular exposure 9, 18, 65 Inhibition of CYP 3A4 by dasatinib quinidine exposure 9, 18, 19 Inhibition of Pgp by quinidine dasatinib exposure 9, 18, 19 QT interval 19 additive effect monitor ECG Inhibition of CYP 3A4 by nilotinib quinidine exposure 9, 18, 19 QT interval 19 additive effect monitor ECG Diuretics Furosemide Absence of interaction 76 Torasemide Inhibition of CYP 2C9 by imatinib torasemide exposure 9, 18 Inhibition of CYP 2C9 by nilotinib torasemide exposure 9, 18 Hydrochlorothiazide Spironolactone Inhibition of Pgp by spironolactone imatinib exposure 9, 64 Inhibition of Pgp by spironolactone dasatinib exposure 9, 10, 52, 64, 67 Beta blockers Metoprolol Inhibition of CYP 2D6 by imatinib metoprolol exposure 18 Inhibition of Pgp by metoprolol dasatinib exposure 9, 10, 52, 67 Inhibition of CYP 2D6 by nilotinib metoprolol exposure 9, 18, 19 Bisoprolol Inhibition of CYP 2D6 by imatinib bisoprolol exposure 18 Inhibition of CYP 3A4 by dasatinib bisoprolol exposure 9, 18 Inhibition of CYP 2D6 by nilotinib bisoprolol exposure 9, 18, 19 Carvedilol Inhibition of CYP 2C9 and 2D6 by imatinib carvedilol exposure 18 Inhibition of Pgp by carvedilol imatinib exposure 64, 71, 77 Inhibition of Pgp by carvedilol dasatinib exposure 9, 10, 52, 67, 68, 77 Inhibition of CYP 2C9 and 2D6 by nilotinib carvedilol exposure 9, 18, 19 Atenolol Absence of interaction 9 ACE inhibitors Captopril Inhibition of CYP 2D6 by imatinib captopril exposure 18 Inhibition of Pgp by captopril imatinib exposure 9, 18, 23, 64, 70, 72 Inhibition of Pgp by captopril dasatinib exposure 9, 10, 52, 67 Inhibition of CYP 2D6 by nilotinib captopril exposure 9, 18, 19 Enalapril Inhibition of CYP 3A4 by imatinib enalapril exposure 18 Inhibition of Pgp by enalapril imatinib exposure 9, 18, 23, 64, 70, 72 Inhibition of Pgp by enalapril dasatinib exposure 9, 10, 52, 67 Inhibition of CYP 3A4 by nilotinib enalapril exposure 9, 18, 19 Ramipril Lisinopril Inhibition of Pgp by imatinib lisinopril exposure 9, 18, 23, 64, 70, 72 Inhibition of Pgp by lisinopril imatinib exposure 9 Inhibition of Pgp by lisinopril dasatinib exposure 9, 10, 52, 67 AT II receptor blockers Losartan Inhibition of CYP 2C9 and 3A4 by imatinib losartan exposure and losartan bioactivation 9, 18, 19 Inhibition of Pgp by losartan imatinib exposure 9, 18, 19 Inhibition of CYP 3A4 by dasatinib losartan exposure 9, 18 Inhibition of Pgp by losartan dasatinib exposure 9, 10, 52, 67 Inhibition of CYP 2C9 and 3A4 by nilotinib losartan exposure and losartan bioactivation 9, 18, 19 Candesartan Cardiac glycosides Digoxin digoxin absorption 9, 18, 19 unknown mechanism QT interval 19 additive effect monitor ECG QT interval 19 additive effect monitor ECG Inhibition of Pgp by nilotinib digoxin exposure 9, 18, 19 buy cialis online uk

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